abstract：:Genes encoding the olfactory receptors of the "OR37" subfamily of the mouse are characterized by special features including a clustered expression pattern, assembly in two distinct gene clusters, and highly conserved putative promoter motifs. Mining the rat and dog databases revealed that these two species possess hig...

journal_title：Journal of molecular evolution

authors： Hoppe R,Lambert TD,Samollow PB,Breer H,Strotmann J

更新日期：2006-04-01 00:00:00

abstract：:Small heat shock proteins (sHSPs), as one subclass of molecular chaperones, are important for cells to protect proteins under stress conditions. Unlike the large HSPs (represented by Hsp60 and Hsp70), sHSPs are highly divergent in both primary sequences and oligomeric status, with their evolutionary relationships bein...

journal_title：Journal of molecular evolution

authors： Fu X,Jiao W,Chang Z

更新日期：2006-03-01 00:00:00

abstract：:The incomplete correlation between the organismal complexities and the number of genes among eukaryotic organisms can be partially explained by multiple protein products of a gene created by alternative splicing. One type of alternative splicing involves alternative selection of mutually exclusive exons and creates pr...

journal_title：Journal of molecular evolution

authors： Chen YC,Lin WH,Tzeng DW,Chow WY

更新日期：2006-02-01 00:00:00

abstract：:The complete sequence of the mitochondrial genome of the plant parasitic nematode Xiphinema americanum sensu stricto has been determined. At 12626bp it is the smallest metazoan mitochondrial genome reported to date. Genes are transcribed from both strands. Genes coding for 12 proteins, 2 rRNAs and 17 putative tRNAs (w...

journal_title：Journal of molecular evolution

authors： He Y,Jones J,Armstrong M,Lamberti F,Moens M

更新日期：2005-12-01 00:00:00

abstract：:RNA editing affecting chloroplast and mitochondrial genomes has been identified in all major clades of land plants. The frequency of edited sites varies greatly between lineages but hornworts represent an extreme in propensity for editing in both their chloroplast and mitochondrial genomes. cDNA sequences from seven t...

journal_title：Journal of molecular evolution

authors： Duff RJ,Moore FB

更新日期：2005-11-01 00:00:00

abstract：:We studied the genomic organization of Hox genes in Atlantic salmon (Salmo salar) and made comparisons to that in rainbow trout (Oncorhynchus mykiss), another member of the family Salmonidae. We used these two species to test the hypothesis that the Hox genes would provide evidence for a fourth round of duplication (4...

journal_title：Journal of molecular evolution

authors： Moghadam HK,Ferguson MM,Danzmann RG

更新日期：2005-11-01 00:00:00

abstract：:Sequence divergence among orthologous proteins was characterized with 34 amino acid replacement matrices, sequence context analysis, and a phylogenetic tree. The model was trained on very large datasets of aligned protein sequences drawn from 15 organisms including protists, plants, Dictyostelium, fungi, and animals. ...

journal_title：Journal of molecular evolution

authors： Olsen R,Loomis WF

更新日期：2005-11-01 00:00:00

abstract：:Molecular domestication of a transposable element is defined as its functional recruitment by the host genome. To date, two independent events of molecular domestication of the P transposable element have been described: in the Drosophila obscura species group and in the Drosophila montium species subgroup. These P ne...

journal_title：Journal of molecular evolution

authors： Reiss D,Nouaud D,Ronsseray S,Anxolabéhère D

更新日期：2005-10-01 00:00:00

abstract：:The trnT-trnF region is located in the large single-copy region of the chloroplast genome. It consists of the trnL intron, a group I intron, and the trnT-trnL and trnL-trnF intergenic spacers. We analyzed the evolution of the region in the three genera of the gymnosperm lineage Gnetales (Gnetum, Welwitschia, and Ephed...

journal_title：Journal of molecular evolution

authors： Won H,Renner SS

更新日期：2005-10-01 00:00:00

abstract：:Exon-shuffling is an important mechanism accounting for the origin of many new proteins in eukaryotes. However, its role in the creation of proteins in the ancestor of prokaryotes and eukaryotes is still debatable. Excess of symmetric exons is thought to represent evidence for exon-shuffling since the exchange of exon...

journal_title：Journal of molecular evolution

authors： Vibranovski MD,Sakabe NJ,de Oliveira RS,de Souza SJ

更新日期：2005-09-01 00:00:00

abstract：:In vitro selection of Zn(2+)-dependent RNA-cleaving DNAzymes with activity at 90 degrees C has yielded a diverse spool of selected sequences. The RNA cleavage efficiency was found in all cases to be specific for Zn(2+) over Pb(2+), Ca(2+), Cd(2+), Co(2+), Hg(2+), and Mg(2+). The Zn(2+)-dependent activity assay of the ...

journal_title：Journal of molecular evolution

authors： Nelson KE,Bruesehoff PJ,Lu Y

更新日期：2005-08-01 00:00:00

abstract：:Sequences from nuclear mitochondrial pseudogenes (numts) that originated by transfer of genetic information from mitochondria to the nucleus offer a unique opportunity to compare different regimes of molecular evolution. Analyzing a 1621-nt-long numt of the rRNA specifying mitochondrial DNA residing on human chromosom...

journal_title：Journal of molecular evolution

authors： Schmitz J,Piskurek O,Zischler H

更新日期：2005-07-01 00:00:00

abstract：:Pituitary prolactin, like growth hormone (GH) and several other protein hormones, shows an episodic pattern of molecular evolution in which sustained bursts of rapid change contrast with long periods of slow evolution. A period of rapid change occurred in the evolution of prolactin in primates, leading to marked seque...

journal_title：Journal of molecular evolution

authors： Wallis OC,Mac-Kwashie AO,Makri G,Wallis M

更新日期：2005-05-01 00:00:00

abstract：:Many proteins exhibit sequence periodicity, often correlated with a visible structural periodicity. The statistical significance of such periodicity can be assessed by means of a chi-squared-based test, with significance thresholds being calculated from shuffled sequences. Comparison of the complete proteomes of 45 sp...

journal_title：Journal of molecular evolution

authors： Gatherer D,McEwan NR

更新日期：2005-04-01 00:00:00

abstract：:Alu elements are not distributed homogeneously throughout the human genome: old elements are preferentially found in the GC-rich parts of the genome, while young Alus are more often found in the GC-poor parts of the genome. The process giving rise to this differential distribution remains poorly understood. Here we in...

journal_title：Journal of molecular evolution

authors： Belle EM,Webster MT,Eyre-Walker A

更新日期：2005-03-01 00:00:00

abstract：:In this study, the molecular population genetics of the orangutan's alpha-2 globin (HBA2) gene were investigated in order to test for the action of natural selection. Haplotypes from 28 orangutan chromosomes were collected from a 1.46-kilobase region of the alpha-2 globin locus. While many aspects of the data were con...

journal_title：Journal of molecular evolution

authors： Steiper ME,Wolfe ND,Karesh WB,Kilbourn AM,Bosi EJ,Ruvolo M

更新日期：2005-03-01 00:00:00

abstract：:The LMP7 and PSMB5 genes were created through an ancient gene duplication event of their ancestral locus. These proteins contain an active site of proteolysis, and LMP7 replaces PSMB5 as a component of the 20S proteasome after stimulation of cells by interferon-gamma. Replacement of PSMB5 by LMP7 changes the profile o...

journal_title：Journal of molecular evolution

authors： Bos DH

更新日期：2005-02-01 00:00:00

abstract：:Studies so far have correlated the variation in the composition of snake venoms with the target prey population and snake's diet. Here we present the first example of an alternative evolutionary link between venom composition and dietary adaptation of snakes. We describe a dinucleotide deletion in the only three finge...

journal_title：Journal of molecular evolution

authors： Li M,Fry BG,Kini RM

更新日期：2005-01-01 00:00:00

abstract：:Microsporidia are unicellular eukaryotes living as obligate intracellular parasites. Lacking mitochondria, they were initially considered as having diverged before the endosymbiosis at the origin of mitochondria. That microsporidia were primitively amitochondriate was first questioned by the discovery of microsporidia...

journal_title：Journal of molecular evolution

authors： Thomarat F,Vivarès CP,Gouy M

更新日期：2004-12-01 00:00:00

abstract：:Human endogenous retroviruses (HERVs) are the remnants of ancient germ cell infection by exogenous retroviruses and occupy up to 8% of the human genome. It has been suggested that HERV sequences have contributed to primate evolution by regulating the expression of cellular genes and mediating chromosome rearrangements...

journal_title：Journal of molecular evolution

authors： Macfarlane C,Simmonds P

更新日期：2004-11-01 00:00:00

abstract：:Members of the serpin (serine protease inhibitor) superfamily of genes are well represented in both human and murine genomes. In many cases it is possible to identify a definite ortholog on the basis of sequence similarity and by examining the surrounding genes at syntenic loci. We have recently examined the murine se...

journal_title：Journal of molecular evolution

authors： Horvath AJ,Forsyth SL,Coughlin PB

更新日期：2004-10-01 00:00:00

abstract：:The pentose phosphate cycle is considered as a major source of NADPH and pentose needed for nucleic acid biosynthesis. 6-Phosphogluconate dehydrogenase (6PGD), an enzyme participating in this cycle, catalyzes the oxidative decarboxylation of 6PGD to ribulose 5-phosphate with the subsequent release of CO2 and the reduc...

journal_title：Journal of molecular evolution

authors： Goulielmos GN,Eliopoulos E,Loukas M,Tsakas S

更新日期：2004-09-01 00:00:00

abstract：:Complement control proteins (CCPs) contain repeated protein domains, short consensus repeats (SCRs), which must be relevant to diverse functions such as complement activation, coagulation, viral binding, fetal implantation, and self-nonself recognition. Although SCRs share some discontinuous and imperfect motifs, ther...

journal_title：Journal of molecular evolution

authors： McLure CA,Dawkins RL,Williamson JF,Davies RA,Berry J,Natalie LJ,Laird R,Gaudieri S

更新日期：2004-08-01 00:00:00

abstract：:The best reconstructions of the history of life will use both molecular time estimates and fossil data. Errors in molecular rate estimation typically are unaccounted for and no attempts have been made to quantify this uncertainty comprehensively. Here, focus is primarily on fossil calibration error because this error ...

journal_title：Journal of molecular evolution

authors： van Tuinen M,Hadly EA

更新日期：2004-08-01 00:00:00

abstract：:We examined the cis- vs. trans-splicing status of the mitochondrial group II intron nad1i728 in 439 species (427 genera) of land plants, using both Southern hybridization results (for 416 species) and intron sequence data from the literature. A total of 164 species (157 genera), all angiosperms, was found to have a tr...

journal_title：Journal of molecular evolution

authors： Qiu YL,Palmer JD

更新日期：2004-07-01 00:00:00

abstract：:Recombination has been suggested to be an important factor for the genetic variation of bacterial genes, but few studies have dealt with intragenic recombination between the same or closely related species of cyanobacteria. Here we provide strong evidence for recombination in the microcystin synthetase (mcy) gene clus...

journal_title：Journal of molecular evolution

authors： Tanabe Y,Kaya K,Watanabe MM

更新日期：2004-06-01 00:00:00

abstract：:The first intron of the gene encoding one of the alcohol dehydrogenase isoenzymes (ADH-1) in Ceratitis capitata is highly polymorphic in size. Five size variants of this intron were isolated from different strains and populations and characterized. Restriction map and sequence analysis showed that the intron size poly...

journal_title：Journal of molecular evolution

authors： Gomulski LM,Brogna S,Babaratsas A,Gasperi G,Zacharopoulou A,Savakis C,Bourtzis K

更新日期：2004-06-01 00:00:00

abstract：:We have further characterized the Asian genotypes (Types 2 and 7) and subtypes of JC virus (JCV). Urine samples from 224 individuals with Han and Mongolian populations were collected in five regions in eastern China: Kunming, Chengdu, Shenyang, Chifeng, and Manzhouli. Also, 99 urine samples were collected from coastal...

journal_title：Journal of molecular evolution

authors： Cui X,Wang JC,Deckhut A,Joseph BC,Eberwein P,Cubitt CL,Ryschkewitsch CF,Agostini HT,Stoner GL

更新日期：2004-05-01 00:00:00

abstract：:We describe the complete mitochondrial genome of the house centipede Scutigera coleoptrata. Its gene order is unique among characterized arthropod mitochondrial genomes. Comparison to the gene order in the horseshoe crab mtDNA implies 10 or more translocations. By extending comparisons to 30 arthropod mitochondrial ge...

journal_title：Journal of molecular evolution

authors： Negrisolo E,Minelli A,Valle G

更新日期：2004-04-01 00:00:00

abstract：:An emergent problem in the study of pathogen evolution is our ability to determine the extent to which their rapidly evolving genomes recombine. Such information is necessary and essential for locating pathogenicity loci using association studies, and it also directs future screening, therapeutic and vaccination strat...

journal_title：Journal of molecular evolution

authors： Greenspan G,Geiger D,Gotch F,Bower M,Patterson S,Nelson M,Gazzard B,Stebbing J

更新日期：2004-03-01 00:00:00

abstract：:Type 1 (archaeal) rhodopsins and related rhodopsin-like proteins had been described in a few halophile archaea, gamma-proteobacteria, a single cyanobacteria, some fungi, and a green alga. In exhaustive database searches, we detected rhodopsin-related sequences derived not only from additional fungal species but also f...

journal_title：Journal of molecular evolution

authors： Ruiz-González MX,Marín I

更新日期：2004-03-01 00:00:00

abstract：:We have investigated the evolvability of an insoluble random polypeptide, RP3-34, to a soluble form through iterative mutation and selection with the aid of the green fluorescent protein (GFP) folding reporter. To assess the solubility of the polypeptides in the selected clones of each generation, the polypeptide gene...

journal_title：Journal of molecular evolution

authors： Ito Y,Kawama T,Urabe I,Yomo T

更新日期：2004-02-01 00:00:00

abstract：:A systematic way of inferring evolutionary relatedness of microbial organisms from the oligopeptide content, i.e., frequency of amino acid K-strings in their complete proteomes, is proposed. The new method circumvents the ambiguity of choosing the genes for phylogenetic reconstruction and avoids the necessity of align...

journal_title：Journal of molecular evolution

authors： Qi J,Wang B,Hao BI

更新日期：2004-01-01 00:00:00

abstract：:LINE-1 (L1) elements constitute the major family of retrotransposons in mammalian genomes. Here we report the first investigation of L1 evolution in New World monkeys (NWM). Two regions of the second open-reading frame were analyzed by two methods in three NWM species, the squirrel monkey (Saimiri sciureus), the tamar...

journal_title：Journal of molecular evolution

authors： Boissinot S,Roos C,Furano AV

更新日期：2004-01-01 00:00:00

abstract：:The evolution of viral genomes has recently attracted considerable attention. We compare the sequences of two large viral genomes, EsV-1 and FirrV-1, belonging to the family of phaeoviruses which infect different species of marine brown algae. Although their genomes differ substantially in size, these viruses share si...

journal_title：Journal of molecular evolution

authors： Delaroque N,Boland W,Müller DG,Knippers R

更新日期：2003-12-01 00:00:00

abstract：:Group I introns are mobile RNA enzymes (ribozymes) that encode conserved primary and secondary structures required for autocatalysis. The group I intron that interrupts the tRNA-Leu gene in cyanobacteria and plastids is remarkable because it is the oldest known intervening sequence and may have been present in the com...

journal_title：Journal of molecular evolution

authors： Simon D,Fewer D,Friedl T,Bhattacharya D

更新日期：2003-12-01 00:00:00

abstract：:RNA polymerase III promoter is located within the coding region in all eukaryotic tRNA genes, whereas in prokaryotic tRNA genes, the promoter is located upstream of the transcription initiation site. We analyzed the nucleotide sequence context of the A and B boxes of RNA polymerase III promoters from different unicell...

journal_title：Journal of molecular evolution

authors： Naykova TM,Kondrakhin YV,Rogozin IB,Voevoda MI,Yudin NS,Romaschenko AG

更新日期：2003-11-01 00:00:00

abstract：:Eukaryotic Nramp genes encode divalent metal ion permeases important for nutrition and resistance to microbial infection. Bacterial homologs encode proton-dependent transporters of manganese (MntH), and other divalent metal ions. Bacterial MntH were classified in three homology groups (A, B, C) and MntH C further subd...

journal_title：Journal of molecular evolution

authors： Richer E,Courville P,Bergevin I,Cellier MF

更新日期：2003-10-01 00:00:00

abstract：:MgtC is a virulence factor required for intramacrophage survival and growth in low Mg2+ medium in two pathogens that are not phylogenetically related, Salmonella typhimurium and Mycobacterium tuberculosis. In S. typhimurium, mgtC is carried by the SPI-3 pathogenicity island and hybridization studies have suggested tha...

journal_title：Journal of molecular evolution

authors： Blanc-Potard AB,Lafay B

更新日期：2003-10-01 00:00:00

abstract：:The evolution of ligand specificity underlies many important problems in biology, from the appearance of drug resistant pathogens to the re-engineering of substrate specificity in enzymes. In studying biomolecules, however, the contributions of macromolecular sequence to binding specificity can be obscured by other se...

journal_title：Journal of molecular evolution

authors： Held DM,Greathouse ST,Agrawal A,Burke DH

更新日期：2003-09-01 00:00:00